Project Name An analysis of the composition of viruses and bacteria in stool samples from IBD patients and healthy controls. 
Domain (1) viruses
Investigators (0) N/A
Institution WASHINGTON UNIVERSITY SCHOOL OF MEDICINE
Project Code PRJEB7772
Project Type metagenome


Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn’s disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease- and cohort-specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.


No assemblies.


Sample Name PI Desc Cart
1 NA
10 NA
100 NA
101 NA
102 NA
103 NA
104 NA
105 NA
106 NA
107 NA
108 NA
109 NA
11 NA
110 NA
111 NA
112 NA
113 NA
114 NA
115 NA
116 NA
117 NA
118 NA
119 NA
12 NA
120 NA
121 NA
122 NA
123 NA
124 NA
125 NA
126 NA
127 NA
128 NA
129 NA
13 NA
130 NA
131 NA
132 NA
133 NA
134 NA
135 NA
136 NA
137 NA
138 NA
139 NA
14 NA
140 NA
141 NA
142 NA
143 NA
144 NA
145 NA
146 NA
147 NA
148 NA
149 NA
15 NA
150 NA
151 NA
152 NA
153 NA
154 NA
155 NA
156 NA
157 NA
158 NA
159 NA
16 NA
160 NA
161 NA
162 NA
163 NA
164 NA
165 NA
166 NA
167 NA
168 NA
169 NA
17 NA
170 NA
171 NA
18 NA
19 NA
2 NA
20 NA
21 NA
22 NA
23 NA
24 NA
25 NA
26 NA
27 NA
28 NA
29 NA
3 NA
30 NA
31 NA
32 NA
33 NA
34 NA
35 NA
36 NA
37 NA
38 NA
39 NA
4 NA
40 NA
41 NA
42 NA
43 NA
44 NA
45 NA
46 NA
47 NA
48 NA
49 NA
5 NA
50 NA
51 NA
52 NA
53 NA
54 NA
55 NA
56 NA
57 NA
58 NA
59 NA
6 NA
60 NA
61 NA
62 NA
63 NA
64 NA
65 NA
66 NA
67 NA
68 NA
69 NA
7 NA
70 NA
71 NA
72 NA
73 NA
74 NA
75 NA
76 NA
77 NA
78 NA
79 NA
8 NA
80 NA
81 NA
82 NA
83 NA
84 NA
85 NA
86 NA
87 NA
88 NA
89 NA
9 NA
90 NA
91 NA
92 NA
93 NA
94 NA
95 NA
96 NA
97 NA
98 NA
99 NA


Type Location
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